Metabolism and Elimination of Toxicants


The foundation of toxicology includes the absorption, distribution, metabolism, and excretion (ADME) of a poisonous agent. Knowledge of those approaches is crucial to assess threat of publicity to poisonous materials Absorption may also arise via the GI tract, skin, lungs, through the eye, mammary gland, or uterus, in addition to from websites of injection Distribution or translocation of a poisonous agent is through the bloodstream to reactive websites, which include garage depots.



The liver gets the portal stream and is the organ maximum generally worried with intoxication (and detoxification) Metabolism or biotransformation of poisonous dealers via way of means of the frame is an “try to detoxify.” In a few instances, metabolized xenobiotic dealers are extra poisonous than the unique compound. This is called deadly synthesis. Metabolism of many organ phosphorous pesticides produces metabolites extra poisonous than the initial (or parent) compounds (e.g., parathion to pyroxene). Excretion of maximum poisonous dealers and their metabolites is through the kidneys. Some excretion takes place with inside the GI tract and a few through the mammary gland in females



 


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